Endocrine Abstracts

Aim: The incidence of nodular thyroid disease is high among patients with insulin resistance. The aim of this study is to evaluate the relationship between BRAFV600E mutation and insulin resistance in the patients with papillary thyroid cancer.Materials and methods: We examined clinical and laboratory data of 103 patients who had been followed up by our department between the years 2010 and 2015. The diagnosis of insulin resistance (IR) was made when the...

Aim: It is well known that there is a strong relationship between chronic inflammation and tumorigenic process. The cytological diagnosis of follicular neoplasm (FN) carries a 20–30% risk of malignancy for thyroid nodules. In this study, we aimed to evaluate whether preoperative neutrophil to lymphocyte ratio (NLR) is a predictive factor for malignancy in thyroid nodules diagnosed as FN on cytology.Materials and methods: A total of 139 patients with...

Purpose: Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. We aim to investigate the relation between the upper abdominal obesity and breast cancer, by using ultrasonography (USG).Material and methods: The study population consisted of 44 women in control group and 17 breast cancer patient in study group. In the whole study population fat tissue was measured with high resolution B-mode...

Primary hyperparathyroidism in the most common cause of hypercalcemia. 87% of the cases present with single adenoma, 9% of them have hyperplasia, while multiple adenomas and parathyroid malignancy are detected in 3 and 1% of the cases, respectively. Although it is rare, parathyroid adenomas may be ectopic. The most common locations for ectopic parathyroid adenomas are thymus, tracheaesophageal cleft, carotis sheet, intrathyroidal and paraesophageal area. In this study, we aime...

Aim: There are some studies suggesting that the risk of developing cancers,especially thyroid cancer, is increased in the patients with acromegaly. The prevalence of thyroid cancer is 1.2-10.6% among the patients with acromegaly. In this study, we aimed to evaluate clinical and histopathologic characteristics of thyroid cancer among the patients with acromegaly.Method: We retrospectively evaluated the patients with acromegaly who had been followed-up by ...

Hyalinizing trabecular tumor is an uncommon, controversial lesion of thyroid gland. Hyalinizing trabecular neoplasm share similarities with medullary thyroid carcinomas (MTC) and exhibit nuclear features resembling papillary thyroid carcinoma (PTC). However, the clinical behaviour unclear. We aimed to present a rare case of hyalinizing trabecular tumor of thyroid gland and ten-year follow up. A 54-year-old woman who was being followed up because of multinodular goiter on exami...

Aim: BRAF is one of the serine threonin kinases that activates mitogen activated protein kinase (MAPK) signal pathway.The aim of this study is to evaluatethe relationship between extrathyroidal extension (ETE) and BRAFV600E mutation in the subjects with papillary thyroid cancer.Materials and methods: Clinical and laboratory data of 455 patients, who had been followed-up in our clinic between the years 2010 and 2015 for PTC, were evaluated. The relationsh...

Aim: ATA guideline recommends complementary thyroidectomy after thyroid lobectomy in case of tumor diameter>1 cm, in the presence of metastatic tumor, invasion, history of radiation therapy, familial history of thyroid cancer, multifocal or agressive variant tumor. In this study, we aimed to evaluate the relationship between the necessity of complementary thyroidectomy and post-surgery clinical, radiologic and histopathologic results in the patients who underwent complemen...

Introduction: Co-occurence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same patient is unusual. We report a case with this rare event.Case: A 39 year old woman was presented with cough and shortness of breath. She had no prior history of radiation exposure, cigarette or alcohol consumption and no family history of thyroid cancer. On physical examination, a 3x5 cm thyroid nodule was palpated in the middle portion of thyroid gland...

Resistance to thyroid hormone (RTH) is a genetic disease characterized by a reduced target tissue responsiveness to thyroid hormones and increased or normal TSH level despite elevated levels of thyroid hormones. This condition is mainly caused by mutations of thyroid hormone receptor beta (THRB) gene. The role of THRB mutation in carcinogenesis is still unclear. In here, we report a case of papillary thyroid carcinoma (PTC) with RTH, with a past medical history of subtotal thy...